"Actor/comedian Bernie Mac passed away this morning from complications due to pneumonia in a Chicago area hospital," his publicist, Danica Smith, said in a statement from Los Angeles, California.
She said no other details were available and asked that his family's privacy be respected.
The comedian suffered from sarcoidosis, an inflammatory lung disease that produces tiny lumps of cells in the body's organs, but had said the condition went into remission in 2005. He recently was hospitalized and treated for pneumonia, which his publicist said was not related to the disease.
Bernie leaves behind a wife and daughter.